A field trial was conducted to evaluate the impact of soil solarization and cattle urine used alone or in combination on the agro-economic performance of irish potato (Solanum tuberosum var. Dosa). To achieve this, a completely randomized block experimental design was established, involving five treatments (chemical fertilizer, soil solarization, cattle urine, soil solarization-cattle urine, negative control), each of which was repeated four times. Data on growth variables (plant height), yield (tuber diameter, number of tubers per plant, yield per hectare), and plant diseases survey (severity and diseases index) were analyzed. An economic analysis involved the assessment of profits derived from treatments. Results indicate that the chemical fertilizer and soil solarization- cattle urine treatments positively affected the potato growth and yield. The highest yields accounted for chemical fertilizer (3.02 t/ha) and soil solarization-cattle urine (2.47 t/ha),compared to solely cattle urine (2.02 t/ha), solarization (1.63 t/ha), and the negative control (0.41 t/ha). Chemical and solarization + urine treatments lowered the severity rates of diseases to average 56% and 62.75% respectively. Treatments cattle urine, soil solarization, and their synergic effect significantly reduced disease incidence compared to the negative control, at respective rates of 1.07%, 0.97%, and 0.93%. The economic analysis indicated that cattle urine is the most suitable treatment under farmers’ conditions, eco-friendly alternative strategy to boost irish potatoes production in the field.